Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DUSP18-20-RE | 20 (40 μL) | 200 μL |  |
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| DUSP18-20-OR | 20 (40 μL) | 200 μL |  |
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| DUSP18-20-GO | 20 (40 μL) | 200 μL |  |
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| DUSP18-20-GR | 20 (40 μL) | 200 μL |  |
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| DUSP18-20-AQ | 20 (40 μL) | 200 μL |  |
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Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Gene Symbol : DUSP18
Gene Name : Dual specificity phosphatase 18
Chromosome : CHR 22: 306,678,89-306,520,50
Locus : 22q12.2
Alt. Genes : FAM13A
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