DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DVL1-20-RE | 20 (40 μL) | 200 μL |  |
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| DVL1-20-OR | 20 (40 μL) | 200 μL |  |
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| DVL1-20-GO | 20 (40 μL) | 200 μL |  |
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| DVL1-20-GR | 20 (40 μL) | 200 μL |  |
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| DVL1-20-AQ | 20 (40 μL) | 200 μL |  |
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DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
Gene Symbol : DVL1
Gene Name : Dishevelled segment polarity protein 1
Chromosome : CHR 1: 134,914,1-133,527,7
Locus : 1p36.33
Alt. Genes : FEM1B
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