This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EDARADD-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| EDARADD-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| EDARADD-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| EDARADD-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| EDARADD-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Symbol : EDARADD
Gene Name : EDAR associated death domain
Chromosome : CHR 1: 236,394,379-236,484,707
Locus : 1q42.3-q43
Alt. Genes : ZNF263
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.