The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EIF2AK3-20-RE | 20 (40 μL) | 200 μL |  |
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| EIF2AK3-20-OR | 20 (40 μL) | 200 μL |  |
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| EIF2AK3-20-GO | 20 (40 μL) | 200 μL |  |
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| EIF2AK3-20-GR | 20 (40 μL) | 200 μL |  |
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| EIF2AK3-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Gene Symbol : EIF2AK3
Gene Name : Eukaryotic translation initiation factor 2 alpha kinase 3
Chromosome : CHR 2: 886,275,75-885,567,39
Locus : 2p11.2
Alt. Genes : HIPK3
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