The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EIF4G1-20-RE | 20 (40 μL) | 200 μL |  |
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| EIF4G1-20-OR | 20 (40 μL) | 200 μL |  |
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| EIF4G1-20-GO | 20 (40 μL) | 200 μL |  |
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| EIF4G1-20-GR | 20 (40 μL) | 200 μL |  |
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| EIF4G1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
Gene Symbol : EIF4G1
Gene Name : Eukaryotic translation initiation factor 4 gamma 1
Chromosome : CHR 3: 184,314,494-184,335,357
Locus : 3q27.1
Alt. Genes : ZNF263
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