The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ELAC2-20-RE | 20 (40 μL) | 200 μL |  |
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| ELAC2-20-OR | 20 (40 μL) | 200 μL |  |
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| ELAC2-20-GO | 20 (40 μL) | 200 μL |  |
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| ELAC2-20-GR | 20 (40 μL) | 200 μL |  |
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| ELAC2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Symbol : ELAC2
Gene Name : ElaC ribonuclease Z 2
Chromosome : CHR 17: 130,180,63-129,916,11
Locus : 17p12
Alt. Genes : FAM13A
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