This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EOGT-20-RE | 20 (40 μL) | 200 μL |  |
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| EOGT-20-OR | 20 (40 μL) | 200 μL |  |
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| EOGT-20-GO | 20 (40 μL) | 200 μL |  |
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| EOGT-20-GR | 20 (40 μL) | 200 μL |  |
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| EOGT-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Gene Symbol : EOGT
Gene Name : EGF domain specific O-linked N-acetylglucosamine transferase
Chromosome : CHR 3: 690,139,60-689,752,11
Locus : 3p14.1
Alt. Genes : ZNF263
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