This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERCC8-20-RE | 20 (40 μL) | 200 μL |  |
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| ERCC8-20-OR | 20 (40 μL) | 200 μL |  |
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| ERCC8-20-GO | 20 (40 μL) | 200 μL |  |
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| ERCC8-20-GR | 20 (40 μL) | 200 μL |  |
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| ERCC8-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
Gene Symbol : ERCC8
Gene Name : ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Chromosome : CHR 5: 609,450,77-608,738,31
Locus : 5q12.1
Alt. Genes : OPTN
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