The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FBXL18-20-RE | 20 (40 μL) | 200 μL |  |
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| FBXL18-20-OR | 20 (40 μL) | 200 μL |  |
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| FBXL18-20-GO | 20 (40 μL) | 200 μL |  |
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| FBXL18-20-GR | 20 (40 μL) | 200 μL |  |
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| FBXL18-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
Gene Symbol : FBXL18
Gene Name : F-box and leucine rich repeat protein 18
Chromosome : CHR 7: 551,381,2-545,444,7
Locus : 7p22.1
Alt. Genes : KIF20A
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