This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FENDRR-20-RE | 20 (40 μL) | 200 μL |  |
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| FENDRR-20-OR | 20 (40 μL) | 200 μL |  |
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| FENDRR-20-GO | 20 (40 μL) | 200 μL |  |
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| FENDRR-20-GR | 20 (40 μL) | 200 μL |  |
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| FENDRR-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Gene Symbol : FENDRR
Gene Name : FOXF1 adjacent non-coding developmental regulatory RNA
Chromosome : CHR 16: 865,088,59-864,745,24
Locus : 16q24.1
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