The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FLG-20-RE | 20 (40 μL) | 200 μL |  |
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| FLG-20-OR | 20 (40 μL) | 200 μL |  |
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| FLG-20-GO | 20 (40 μL) | 200 μL |  |
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| FLG-20-GR | 20 (40 μL) | 200 μL |  |
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| FLG-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Gene Symbol : FLG
Gene Name : Filaggrin
Chromosome : CHR 1: 152,325,202-152,302,174
Locus : 1q21.3
Alt. Genes : C1QA
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