The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FLG2-20-RE | 20 (40 μL) | 200 μL |  |
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| FLG2-20-OR | 20 (40 μL) | 200 μL |  |
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| FLG2-20-GO | 20 (40 μL) | 200 μL |  |
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| FLG2-20-GR | 20 (40 μL) | 200 μL |  |
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| FLG2-20-AQ | 20 (40 μL) | 200 μL |  |
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The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]
Gene Symbol : FLG2
Gene Name : Filaggrin family member 2
Chromosome : CHR 1: 152,360,027-152,348,734
Locus : 1q21.3
Alt. Genes : SLC35A1
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