This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FMN2-20-RE | 20 (40 μL) | 200 μL |  |
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| FMN2-20-OR | 20 (40 μL) | 200 μL |  |
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| FMN2-20-GO | 20 (40 μL) | 200 μL |  |
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| FMN2-20-GR | 20 (40 μL) | 200 μL |  |
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| FMN2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the formin homology protein family. The encoded protein is thought to have essential roles in organization of the actin cytoskeleton and in cell polarity. This protein mediates the formation of an actin mesh that positions the spindle during oogenesis and also regulates the formation of actin filaments in the nucleus. This protein also forms a perinuclear actin/focal-adhesion system that regulates the shape and position of the nucleus during cell migration. Mutations in this gene have been associated with infertility and also with an autosomal recessive form of intellectual disability (MRT47). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2017]
Gene Symbol : FMN2
Gene Name : Formin 2
Chromosome : CHR 1: 240,013,775-240,475,188
Locus : 1q43
Alt. Genes : OPTN
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