This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FRMD4A-20-RE | 20 (40 μL) | 200 μL |  |
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| FRMD4A-20-OR | 20 (40 μL) | 200 μL |  |
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| FRMD4A-20-GO | 20 (40 μL) | 200 μL |  |
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| FRMD4A-20-GR | 20 (40 μL) | 200 μL |  |
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| FRMD4A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Symbol : FRMD4A
Gene Name : FERM domain containing 4A
Chromosome : CHR 10: 143,309,51-136,437,05
Locus : 10p13
Alt. Genes : ZNF263
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