This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GABRA1-20-RE | 20 (40 μL) | 200 μL |  |
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| GABRA1-20-OR | 20 (40 μL) | 200 μL |  |
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| GABRA1-20-GO | 20 (40 μL) | 200 μL |  |
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| GABRA1-20-GR | 20 (40 μL) | 200 μL |  |
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| GABRA1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : GABRA1
Gene Name : Gamma-aminobutyric acid type A receptor alpha1 subunit
Chromosome : CHR 5: 161,847,190-161,899,958
Locus : 5q34
Alt. Genes : OPTN
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