Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GABRA4-20-RE | 20 (40 μL) | 200 μL |  |
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| GABRA4-20-OR | 20 (40 μL) | 200 μL |  |
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| GABRA4-20-GO | 20 (40 μL) | 200 μL |  |
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| GABRA4-20-GR | 20 (40 μL) | 200 μL |  |
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| GABRA4-20-AQ | 20 (40 μL) | 200 μL |  |
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Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
Gene Symbol : GABRA4
Gene Name : Gamma-aminobutyric acid type A receptor alpha4 subunit
Chromosome : CHR 4: 469,944,06-469,188,99
Locus : 4p12
Alt. Genes : YAF2
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