This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GADD45A-20-RE | 20 (40 μL) | 200 μL |  |
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| GADD45A-20-OR | 20 (40 μL) | 200 μL |  |
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| GADD45A-20-GO | 20 (40 μL) | 200 μL |  |
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| GADD45A-20-GR | 20 (40 μL) | 200 μL |  |
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| GADD45A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Gene Symbol : GADD45A
Gene Name : Growth arrest and DNA damage inducible alpha
Chromosome : CHR 1: 676,851,76-676,883,37
Locus : 1p31.3
Alt. Genes : TRIM28
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