This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GCNT2-20-RE | 20 (40 μL) | 200 μL |  |
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| GCNT2-20-OR | 20 (40 μL) | 200 μL |  |
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| GCNT2-20-GO | 20 (40 μL) | 200 μL |  |
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| GCNT2-20-GR | 20 (40 μL) | 200 μL |  |
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| GCNT2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Symbol : GCNT2
Gene Name : Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
Chromosome : CHR 6: 105,212,82-106,293,67
Locus : 6p24.3-p24.2
Alt. Genes : MRPS31
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