The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GDAP1L1-20-RE | 20 (40 μL) | 200 μL |  |
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| GDAP1L1-20-OR | 20 (40 μL) | 200 μL |  |
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| GDAP1L1-20-GO | 20 (40 μL) | 200 μL |  |
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| GDAP1L1-20-GR | 20 (40 μL) | 200 μL |  |
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| GDAP1L1-20-AQ | 20 (40 μL) | 200 μL |  |
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The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Symbol : GDAP1L1
Gene Name : Ganglioside induced differentiation associated protein 1 like 1
Chromosome : CHR 20: 442,470,98-442,809,16
Locus : 20q13.12
Alt. Genes : LRPPRC
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