Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GGTLC3-20-RE | 20 (40 μL) | 200 μL |  |
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| GGTLC3-20-OR | 20 (40 μL) | 200 μL |  |
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| GGTLC3-20-GO | 20 (40 μL) | 200 μL |  |
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| GGTLC3-20-GR | 20 (40 μL) | 200 μL |  |
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| GGTLC3-20-AQ | 20 (40 μL) | 200 μL |  |
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Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Gene Symbol : GGTLC3
Gene Name : Gamma-glutamyltransferase light chain 3
Chromosome : CHR 22: 185,181,60-185,163,37
Locus : 22q11.21
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