Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GLDC-20-RE | 20 (40 μL) | 200 μL |  |
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| GLDC-20-OR | 20 (40 μL) | 200 μL |  |
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| GLDC-20-GO | 20 (40 μL) | 200 μL |  |
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| GLDC-20-GR | 20 (40 μL) | 200 μL |  |
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| GLDC-20-AQ | 20 (40 μL) | 200 μL |  |
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Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Gene Symbol : GLDC
Gene Name : Glycine decarboxylase
Chromosome : CHR 9: 664,569,1-653,246,3
Locus : 9p24.1
Alt. Genes : FEM1B
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