GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GMDS-20-RE | 20 (40 μL) | 200 μL |  |
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| GMDS-20-OR | 20 (40 μL) | 200 μL |  |
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| GMDS-20-GO | 20 (40 μL) | 200 μL |  |
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| GMDS-20-GR | 20 (40 μL) | 200 μL |  |
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| GMDS-20-AQ | 20 (40 μL) | 200 μL |  |
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GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Gene Symbol : GMDS
Gene Name : GDP-mannose 4,6-dehydratase
Chromosome : CHR 6: 224,563,3-162,379,9
Locus : 6p25.3
Alt. Genes : HIPK3
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