This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GPBAR1-20-RE | 20 (40 μL) | 200 μL |  |
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| GPBAR1-20-OR | 20 (40 μL) | 200 μL |  |
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| GPBAR1-20-GO | 20 (40 μL) | 200 μL |  |
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| GPBAR1-20-GR | 20 (40 μL) | 200 μL |  |
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| GPBAR1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Symbol : GPBAR1
Gene Name : G protein-coupled bile acid receptor 1
Chromosome : CHR 2: 218,259,495-218,263,860
Locus : 2q35
Alt. Genes : CELA3A
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