This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GPT2-20-RE | 20 (40 μL) | 200 μL |  |
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| GPT2-20-OR | 20 (40 μL) | 200 μL |  |
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| GPT2-20-GO | 20 (40 μL) | 200 μL |  |
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| GPT2-20-GR | 20 (40 μL) | 200 μL |  |
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| GPT2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Symbol : GPT2
Gene Name : Glutamic--pyruvic transaminase 2
Chromosome : CHR 16: 468,843,79-469,312,96
Locus : 16q11.2
Alt. Genes : CELA3A
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