Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GSAP-20-RE | 20 (40 μL) | 200 μL |  |
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| GSAP-20-OR | 20 (40 μL) | 200 μL |  |
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| GSAP-20-GO | 20 (40 μL) | 200 μL |  |
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| GSAP-20-GR | 20 (40 μL) | 200 μL |  |
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| GSAP-20-AQ | 20 (40 μL) | 200 μL |  |
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Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
Gene Symbol : GSAP
Gene Name : Gamma-secretase activating protein
Chromosome : CHR 7: 774,164,28-773,107,50
Locus : 7q11.23
Alt. Genes : RBM12
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