This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GUCY2D-20-RE | 20 (40 μL) | 200 μL |  |
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| GUCY2D-20-OR | 20 (40 μL) | 200 μL |  |
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| GUCY2D-20-GO | 20 (40 μL) | 200 μL |  |
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| GUCY2D-20-GR | 20 (40 μL) | 200 μL |  |
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| GUCY2D-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]
Gene Symbol : GUCY2D
Gene Name : Guanylate cyclase 2D, retinal
Chromosome : CHR 17: 800,266,9-802,033,9
Locus : 17p13.1
Alt. Genes : ABI2
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