This element represents a DNase I hypersensitive site located approximately 111 kb upstream of the HBE1 (hemoglobin, epsilon 1) gene in the beta-globin gene cluster. Chromosome conformation capture assays show that the orthologous mouse hypersensitive site is an integral part of the beta-globin active chromatin hub in erythroid cells, where it undergoes looping interactions with 3'HS1, which is located downstream of the beta-globin gene cluster, and this folding further enables interactions between the beta-globin locus control region (LCR) and active beta-globin gene promoters. [provided by RefSeq, Nov 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HBB-HS-111-20-RE | 20 (40 μL) | 200 μL |  |
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| HBB-HS-111-20-OR | 20 (40 μL) | 200 μL |  |
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| HBB-HS-111-20-GO | 20 (40 μL) | 200 μL |  |
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| HBB-HS-111-20-GR | 20 (40 μL) | 200 μL |  |
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| HBB-HS-111-20-AQ | 20 (40 μL) | 200 μL |  |
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This element represents a DNase I hypersensitive site located approximately 111 kb upstream of the HBE1 (hemoglobin, epsilon 1) gene in the beta-globin gene cluster. Chromosome conformation capture assays show that the orthologous mouse hypersensitive site is an integral part of the beta-globin active chromatin hub in erythroid cells, where it undergoes looping interactions with 3'HS1, which is located downstream of the beta-globin gene cluster, and this folding further enables interactions between the beta-globin locus control region (LCR) and active beta-globin gene promoters. [provided by RefSeq, Nov 2015]
Gene Symbol : HBB-HS-111
Gene Name : Beta-globin hypersensitive site -111
Chromosome : CHR 11: 0-0
Locus : 11p15
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