Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HDAC4-20-RE | 20 (40 μL) | 200 μL |  |
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| HDAC4-20-OR | 20 (40 μL) | 200 μL |  |
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| HDAC4-20-GO | 20 (40 μL) | 200 μL |  |
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| HDAC4-20-GR | 20 (40 μL) | 200 μL |  |
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| HDAC4-20-AQ | 20 (40 μL) | 200 μL |  |
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Symbol : HDAC4
Gene Name : Histone deacetylase 4
Chromosome : CHR 2: 239,401,646-239,048,167
Locus : 2q37.3
Alt. Genes : AKAP9
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