This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354). [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HEPN1-20-RE | 20 (40 μL) | 200 μL |  |
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| HEPN1-20-OR | 20 (40 μL) | 200 μL |  |
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| HEPN1-20-GO | 20 (40 μL) | 200 μL |  |
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| HEPN1-20-GR | 20 (40 μL) | 200 μL |  |
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| HEPN1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354). [provided by RefSeq, Aug 2011]
Gene Symbol : HEPN1
Gene Name : Hepatocellular carcinoma, down-regulated 1
Chromosome : CHR 11: 124,919,249-124,920,676
Locus : 11q24.2
Alt. Genes : ZNF267
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