This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
SKU | Test Kits | Buffer | Dye Color | Order Now |
---|---|---|---|---|
HIF1A-20-RE | 20 (40 μL) | 200 μL | Request Pricing | |
HIF1A-20-OR | 20 (40 μL) | 200 μL | Request Pricing | |
HIF1A-20-GO | 20 (40 μL) | 200 μL | Request Pricing | |
HIF1A-20-GR | 20 (40 μL) | 200 μL | Request Pricing | |
HIF1A-20-AQ | 20 (40 μL) | 200 μL | Request Pricing |
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Gene Symbol : HIF1A
Gene Name : Hypoxia inducible factor 1 alpha subunit
Chromosome : CHR 14: 616,954,00-617,482,58
Locus : 14q23.2
Alt. Genes : PREB
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