The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HIRIP3-20-RE | 20 (40 μL) | 200 μL |  |
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| HIRIP3-20-OR | 20 (40 μL) | 200 μL |  |
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| HIRIP3-20-GO | 20 (40 μL) | 200 μL |  |
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| HIRIP3-20-GR | 20 (40 μL) | 200 μL |  |
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| HIRIP3-20-AQ | 20 (40 μL) | 200 μL |  |
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The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Gene Symbol : HIRIP3
Gene Name : HIRA interacting protein 3
Chromosome : CHR 16: 299,960,95-299,923,20
Locus : 16p11.2
Alt. Genes : YAF2
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