In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HNMT-20-RE | 20 (40 μL) | 200 μL |  |
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| HNMT-20-OR | 20 (40 μL) | 200 μL |  |
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| HNMT-20-GO | 20 (40 μL) | 200 μL |  |
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| HNMT-20-GR | 20 (40 μL) | 200 μL |  |
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| HNMT-20-AQ | 20 (40 μL) | 200 μL |  |
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In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : HNMT
Gene Name : Histamine N-methyltransferase
Chromosome : CHR 2: 137,964,067-138,016,363
Locus : 2q22.1
Alt. Genes : RASA4
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