This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HOXB8-20-RE | 20 (40 μL) | 200 μL |  |
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| HOXB8-20-OR | 20 (40 μL) | 200 μL |  |
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| HOXB8-20-GO | 20 (40 μL) | 200 μL |  |
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| HOXB8-20-GR | 20 (40 μL) | 200 μL |  |
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| HOXB8-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
Gene Symbol : HOXB8
Gene Name : Homeobox B8
Chromosome : CHR 17: 486,228,52-486,123,45
Locus : 17q21.32
Alt. Genes : EBI3
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