This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HUWE1-20-RE | 20 (40 μL) | 200 μL |  |
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| HUWE1-20-OR | 20 (40 μL) | 200 μL |  |
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| HUWE1-20-GO | 20 (40 μL) | 200 μL |  |
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| HUWE1-20-GR | 20 (40 μL) | 200 μL |  |
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| HUWE1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Gene Symbol : HUWE1
Gene Name : HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
Chromosome : CHR X: 536,867,28-535,320,95
Locus : Xp11.22
Alt. Genes : LRPPRC
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