Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IBTK-20-RE | 20 (40 μL) | 200 μL |  |
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| IBTK-20-OR | 20 (40 μL) | 200 μL |  |
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| IBTK-20-GO | 20 (40 μL) | 200 μL |  |
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| IBTK-20-GR | 20 (40 μL) | 200 μL |  |
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| IBTK-20-AQ | 20 (40 μL) | 200 μL |  |
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Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Symbol : IBTK
Gene Name : Inhibitor of Bruton tyrosine kinase
Chromosome : CHR 6: 822,482,93-821,699,86
Locus : 6q14.1
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