The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL10RA-20-RE | 20 (40 μL) | 200 μL |  |
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| IL10RA-20-OR | 20 (40 μL) | 200 μL |  |
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| IL10RA-20-GO | 20 (40 μL) | 200 μL |  |
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| IL10RA-20-GR | 20 (40 μL) | 200 μL |  |
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| IL10RA-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Symbol : IL10RA
Gene Name : Interleukin 10 receptor subunit alpha
Chromosome : CHR 11: 117,986,390-118,001,482
Locus : 11q23.3
Alt. Genes : CLEC3A
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