The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IL12RB2-20-RE | 20 (40 μL) | 200 μL |  |
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| IL12RB2-20-OR | 20 (40 μL) | 200 μL |  |
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| IL12RB2-20-GO | 20 (40 μL) | 200 μL |  |
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| IL12RB2-20-GR | 20 (40 μL) | 200 μL |  |
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| IL12RB2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Symbol : IL12RB2
Gene Name : Interleukin 12 receptor subunit beta 2
Chromosome : CHR 1: 673,073,50-673,977,29
Locus : 1p31.3
Alt. Genes : RASA4
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