This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IMPDH2-20-RE | 20 (40 μL) | 200 μL |  |
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| IMPDH2-20-OR | 20 (40 μL) | 200 μL |  |
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| IMPDH2-20-GO | 20 (40 μL) | 200 μL |  |
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| IMPDH2-20-GR | 20 (40 μL) | 200 μL |  |
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| IMPDH2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Gene Symbol : IMPDH2
Gene Name : Inosine monophosphate dehydrogenase 2
Chromosome : CHR 3: 490,297,49-490,243,24
Locus : 3p21.31
Alt. Genes : KIF20A
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