This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IRAK4-20-RE | 20 (40 μL) | 200 μL |  |
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| IRAK4-20-OR | 20 (40 μL) | 200 μL |  |
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| IRAK4-20-GO | 20 (40 μL) | 200 μL |  |
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| IRAK4-20-GR | 20 (40 μL) | 200 μL |  |
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| IRAK4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Symbol : IRAK4
Gene Name : Interleukin 1 receptor associated kinase 4
Chromosome : CHR 12: 437,589,12-437,895,42
Locus : 12q12
Alt. Genes : HIPK3
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