The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IRF4-20-RE | 20 (40 μL) | 200 μL |  |
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| IRF4-20-OR | 20 (40 μL) | 200 μL |  |
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| IRF4-20-GO | 20 (40 μL) | 200 μL |  |
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| IRF4-20-GR | 20 (40 μL) | 200 μL |  |
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| IRF4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Symbol : IRF4
Gene Name : Interferon regulatory factor 4
Chromosome : CHR 6: 391,738-411,442
Locus : 6p25.3
Alt. Genes : RAD50
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