This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| IRF6-20-RE | 20 (40 μL) | 200 μL |  |
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| IRF6-20-OR | 20 (40 μL) | 200 μL |  |
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| IRF6-20-GO | 20 (40 μL) | 200 μL |  |
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| IRF6-20-GR | 20 (40 μL) | 200 μL |  |
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| IRF6-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Gene Symbol : IRF6
Gene Name : Interferon regulatory factor 6
Chromosome : CHR 1: 209,806,174-209,785,622
Locus : 1q32.2
Alt. Genes : TRAP1
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