The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITGA4-20-RE | 20 (40 μL) | 200 μL |  |
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| ITGA4-20-OR | 20 (40 μL) | 200 μL |  |
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| ITGA4-20-GO | 20 (40 μL) | 200 μL |  |
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| ITGA4-20-GR | 20 (40 μL) | 200 μL |  |
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| ITGA4-20-AQ | 20 (40 μL) | 200 μL |  |
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The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Symbol : ITGA4
Gene Name : Integrin subunit alpha 4
Chromosome : CHR 2: 181,456,891-181,538,927
Locus : 2q31.3
Alt. Genes : PREB
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