Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITGAE-20-RE | 20 (40 μL) | 200 μL |  |
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| ITGAE-20-OR | 20 (40 μL) | 200 μL |  |
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| ITGAE-20-GO | 20 (40 μL) | 200 μL |  |
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| ITGAE-20-GR | 20 (40 μL) | 200 μL |  |
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| ITGAE-20-AQ | 20 (40 μL) | 200 μL |  |
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Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Gene Symbol : ITGAE
Gene Name : Integrin subunit alpha E
Chromosome : CHR 17: 380,376,5-371,462,4
Locus : 17p13.2
Alt. Genes : ATP6AP2
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