This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITGAM-20-RE | 20 (40 μL) | 200 μL |  |
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| ITGAM-20-OR | 20 (40 μL) | 200 μL |  |
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| ITGAM-20-GO | 20 (40 μL) | 200 μL |  |
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| ITGAM-20-GR | 20 (40 μL) | 200 μL |  |
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| ITGAM-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Symbol : ITGAM
Gene Name : Integrin subunit alpha M
Chromosome : CHR 16: 312,599,66-313,328,91
Locus : 16p11.2
Alt. Genes : LHFPL6
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