This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITGB3BP-20-RE | 20 (40 μL) | 200 μL |  |
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| ITGB3BP-20-OR | 20 (40 μL) | 200 μL |  |
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| ITGB3BP-20-GO | 20 (40 μL) | 200 μL |  |
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| ITGB3BP-20-GR | 20 (40 μL) | 200 μL |  |
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| ITGB3BP-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Symbol : ITGB3BP
Gene Name : Integrin subunit beta 3 binding protein
Chromosome : CHR 1: 635,235,16-634,407,69
Locus : 1p31.3
Alt. Genes : AKAP9
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