Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITM2B-20-RE | 20 (40 μL) | 200 μL |  |
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| ITM2B-20-OR | 20 (40 μL) | 200 μL |  |
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| ITM2B-20-GO | 20 (40 μL) | 200 μL |  |
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| ITM2B-20-GR | 20 (40 μL) | 200 μL |  |
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| ITM2B-20-AQ | 20 (40 μL) | 200 μL |  |
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Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Gene Symbol : ITM2B
Gene Name : Integral membrane protein 2B
Chromosome : CHR 13: 482,331,37-482,620,95
Locus : 13q14.2
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