Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ITPKA-20-RE | 20 (40 μL) | 200 μL |  |
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| ITPKA-20-OR | 20 (40 μL) | 200 μL |  |
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| ITPKA-20-GO | 20 (40 μL) | 200 μL |  |
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| ITPKA-20-GR | 20 (40 μL) | 200 μL |  |
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| ITPKA-20-AQ | 20 (40 μL) | 200 μL |  |
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Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Gene Symbol : ITPKA
Gene Name : Inositol-trisphosphate 3-kinase A
Chromosome : CHR 15: 414,938,57-415,035,58
Locus : 15q15.1
Alt. Genes : ZNF263
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