ITPR2 FISH Probe

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
ITPR2-20-RE 20 (40 μL) 200 μL color Request Pricing
ITPR2-20-OR 20 (40 μL) 200 μL color Request Pricing
ITPR2-20-GO 20 (40 μL) 200 μL color Request Pricing
ITPR2-20-GR 20 (40 μL) 200 μL color Request Pricing
ITPR2-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]

Gene Details

Gene Symbol : ITPR2

Gene Name : Inositol 1,4,5-trisphosphate receptor type 2

Chromosome : CHR 12: 268,331,97-263,353,36

Locus : 12p11.23

Alt. Genes : LRPPRC

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