The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| JMJD1C-20-RE | 20 (40 μL) | 200 μL |  |
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| JMJD1C-20-OR | 20 (40 μL) | 200 μL |  |
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| JMJD1C-20-GO | 20 (40 μL) | 200 μL |  |
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| JMJD1C-20-GR | 20 (40 μL) | 200 μL |  |
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| JMJD1C-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Symbol : JMJD1C
Gene Name : Jumonji domain containing 1C
Chromosome : CHR 10: 635,220,74-631,672,20
Locus : 10q21.3
Alt. Genes : PREB
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