The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| KAT6B-20-RE | 20 (40 μL) | 200 μL |  |
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| KAT6B-20-OR | 20 (40 μL) | 200 μL |  |
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| KAT6B-20-GO | 20 (40 μL) | 200 μL |  |
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| KAT6B-20-GR | 20 (40 μL) | 200 μL |  |
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| KAT6B-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Symbol : KAT6B
Gene Name : Lysine acetyltransferase 6B
Chromosome : CHR 10: 748,249,26-750,326,22
Locus : 10q22.2
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